SML4158
TED-347
≥98% (HPLC)
别名:
2-Chloro-1-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]ethanone
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
O=C(C1=CC=CC=C1NC2=CC(C(F)(F)F)=CC=C2)CCl
一般描述
TED-347is a potent and selective allosteric inhibitor of the transcriptional enhanced associate domain (TEAD)-yes-associated protein 1 (Yap1) protein-protein interaction (EC50 =5.9 µM) that inhibits TEAD transcriptional activity. It potentlyinhibits growth of spheroids of patient-derived GBM43 glioblastoma cell lines.TED-347 binds to the TEAD4 palmitate pocket where it forms covalent bond withCys-367.
应用
TED-347 is used to probe the how dysregulation ofYAP-TEAD signalling relates to glioblastoma proliferations
生化/生理作用
Potent and selective allosteric inhibitor of the TEAD-Yap1 protein-protein interaction that inhibits TEAD transcriptional activity.
TED-347 is a potent and selective allosteric inhibitor of the TEAD-Yap1 protein-protein interaction (EC50 = 5.9 µM) that inhibits TEAD transcriptional activity. TED-347 potently inhibits growth of spheroids of patient-derived GBM43 glioblastoma cell lines. TED-347 binds to the TEAD4 palmitate pocket where it forms covalent bond with Cys-367.
TED-347 is a potent and selective allosteric inhibitor of the TEAD-Yap1 protein-protein interaction (EC50 = 5.9 µM) that inhibits TEAD transcriptional activity. TED-347 potently inhibits growth of spheroids of patient-derived GBM43 glioblastoma cell lines. TED-347 binds to the TEAD4 palmitate pocket where it forms covalent bond with Cys-367.
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持