SMILES string
FC1=CC=CC(Br)=C1NC2=NCCN2.Cl
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Application
Romifidine hydrochloride may be used to study its effects on sedation and pain management in animal models.
Biochem/physiol Actions
Romifidine is an α2-adrenergic receptor (α2-adrenoceptor) agonist with in vivo sedative and analgesic efficacy. Romifidine depresses excitatory postsynaptic potential in a neonatal rat hemisected spinal cord preparation ex vivo (high/low intensity e.p.s.p. EC50 = 23.4/22.0 µM), reversible by the selective α2-adrenoceptor antagonist atipamezole.
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Mohamed Marzok et al.
Frontiers in veterinary science, 9, 966715-966715 (2022-12-27)
Local and regional anesthetic procedures are valuable tools in veterinary practice. Caudal epidural administration of local anesthetic agents is widely reported for surgical interventions of the tail, anus, rectum, vulva, vagina, urethra, and bladder in the standing horse. Epidural analgesia
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