SMILES string
O=C1N(C=C(C=N1)I)[C@@H]2O[C@@H]([C@H](C2)O)CO
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
General description
Ropidoxuridine, a thymidine analog, is an orally available pro-drug of 5-iodo-2′-deoxyuridine (IUdR).
Application
Ropidoxuridine is suitable for use in radiosensitization studies in vivo using cancer models and cell lines.
Biochem/physiol Actions
Ropidoxuridine, a radiation sensitizer, after oral administration it is metabolized by an aldehyde oxidase in the liver to the active drug. Ropidoxuridine sensitizes cancer cells to radiation.
法规信息
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T J Kinsella et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 6(4), 1468-1475 (2000-04-25)
In anticipation of an initial clinical Phase I trial in patients with high-grade gliomas of p.o. administered 5-iodo2-pyrimidinone-2'-deoxyribose (IPdR) given daily for 14 days as a prodrug for 5-iodo-2'-deoxyuridine (IUdR)-mediated tumor radiosensitization, we determined the systemic toxicities and the percentage
Timothy Kinsella et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(20), 6035-6043 (2019-07-25)
Iododeoxyuridine (IUdR) is a potent radiosensitizer; however, its clinical utility is limited by dose-limiting systemic toxicities and the need for prolonged continuous infusion. 5-Iodo-2-pyrimidinone-2'-deoxyribose (IPdR) is an oral prodrug of IUdR that, compared with IUdR, is easier to administer and
Thomas J George et al.
Cancer, 125(16), 2732-2746 (2019-04-25)
Colorectal cancer (CRC) represents a major public health problem as the second leading cause of cancer-related mortality in the United States. Of an estimated 140,000 newly diagnosed CRC cases in 2018, roughly one-third of these patients will have a primary
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