SMILES string
CC(CCC(C1=C(C=C(OC1=O)C)O)=O)C
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Application
Pogostone may be used:
- to study its insecticidal activity against Spodoptera litura (Fabricius) and Spodoptera exigua (Hübner)
- to study its effects on adipose tissue inflammation in vitro and in vivo
- to study its effects on osteolytic bone metastases in mice and investigate the molecular mechanisms of pogostone against cancer-induced osteoclast formation and cancer cell proliferation or migration in vitro
Biochem/physiol Actions
Pogostone is an active ingredient isolated from the essential oil of Pogostemon cablin (patchouli oil) that exhibits various pharmacological properties, including anti-inflammatory and anti-cancer activities. Pogostone attenuates high-fat diet–induced nonalcoholic fatty liver disease (NAFLD) in mice through inhibition of NLRP3 inflammasome signaling.
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Tao Zheng et al.
Life sciences, 328, 121611-121611 (2023-04-18)
Breast cancer is the most prevalent cancer in females, and approximately 70 % of all patients have evidence of metastatic bone disease, which substantially affects the quality of life and survival rate of breast cancer patients. Osteoporosis has become a global
Shengzhao Tang et al.
European journal of pharmacology, 970, 176463-176463 (2024-03-11)
Inhibition of inflammasome activation is a potential therapeutic strategy for treating nonalcoholic fatty liver disease (NAFLD). Pogostone (PO), an active ingredient in Pogostemon cablin, exhibits various pharmacological properties, including anti-inflammation. However, there are no reports of the hepatoprotective effects of
Pogostone Enhances the Antibacterial Activity of Colistin against MCR-1-Positive Bacteria by Inhibiting the Biological Function of MCR-1
Xie S, et al.
Molecules (Basel), 27 (2022)
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