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SML4204

Yaddle1

Name: Yaddle1
Brand: SIGMA

≥98% (HPLC), powder, Piezo1 Agonist

别名:

2-{[2-Chloro-6-(trifluoromethyl)benzyl]thio}-5-(pyrazin-2-yl)-1,3,4-oxadiazole, Pyrazine, 2-[5-[[[2-chloro-6-(trifluoromethyl)phenyl]methyl]thio]-1,3,4-oxadiazol-2-yl]- (ACI)

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关于此项目

经验公式（希尔记法）:

C₁₄H₈ClF₃N₄OS

化学文摘社编号:

3041134-13-5

分子量:

372.75

Assay:

≥98% (HPLC)

Form:

powder

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属性

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

说明

General description

Yaddle1 is designed to interact specifically with the Piezo1 channel. It features a trifluoromethyl group, which is crucial for its agonistic activity.

Application

Yaddle1 may be used in immunology as a vaccine adjuvant, targeting optimal T cell activation, enhancing vaccine efficacy. It may also be used to study the role of piezo-type mechanosensitive ion channel component 1 in inflammatory bowel disease.

Biochem/physiol Actions

Yaddle1 is a mechanosensitive ion channel Piezo1 agonist with higher potency (Ca2+ influx EC50/Emax = 0.40 μM/2.6-fold using Piezo1 mCherry-expressing HEK293A) and greatly improved aqueous solubility (26.7 μM at pH 7.4) than Yoda1 (EC50/Emax = 0.50 μM/2.4-fold; solubility = 1.2 μM at pH 7.4). Yaddle1 binds to Piezo1 channel, stabilizing the open conformation of the Piezo1 channel and lowering the mechanical activation threshold.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c