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SML4206

DMXAA sodium salt

≥98% (HPLC)

别名:

5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid sodium salt; sodium 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetate, 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid sodium salt; 5,6-Dimethylxanthenone-4-acetic acid sodium salt, Vadimezan sodium salt, ASA404 sodium salt, NSC 640488 sodium salt

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关于此项目

经验公式（希尔记法）:
C17H13NaO4
化学文摘社编号:
129095-08-5
分子量:
304.27
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

A water-soluble sodium salt form of DMXAA. DMXAA directly binds to murine STING (stimulator of interferon genes) but does not affect human STING. DMXAA disrupts tumor vasculature by inducing endothelial cell apoptosis, causing tumor hemorrhagic necrosis and ischemia, releasing serotonin, stimulating the innate immune system, producing inflammatory cytokines (e.g., TNF, IL-6, GCSF, KC, IP-10, MCP-1), activating NF-κB and p38 MAPK, producing nitric oxide, and reducing tumor energetics and membrane turnover.

Disclaimer

Hygroscopic Store with desiccant

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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