DMXAA sodium salt

Name: DMXAA sodium salt
Brand: SIGMA

≥98% (HPLC)

别名:

5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid sodium salt; sodium 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetate, 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid sodium salt; 5,6-Dimethylxanthenone-4-acetic acid sodium salt, Vadimezan sodium salt, ASA404 sodium salt, NSC 640488 sodium salt

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₃NaO₄

化学文摘社编号:

129095-08-5

分子量:

304.27

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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属性

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

说明

Biochem/physiol Actions

A water-soluble sodium salt form of DMXAA. DMXAA directly binds to murine STING (stimulator of interferon genes) but does not affect human STING. DMXAA disrupts tumor vasculature by inducing endothelial cell apoptosis, causing tumor hemorrhagic necrosis and ischemia, releasing serotonin, stimulating the innate immune system, producing inflammatory cytokines (e.g., TNF, IL-6, GCSF, KC, IP-10, MCP-1), activating NF-κB and p38 MAPK, producing nitric oxide, and reducing tumor energetics and membrane turnover.