Quality Segment
assay
≥98% (HPLC)
form
powder
color
faint orange to brown
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
I4.05 is an inhibitor of α-synuclein aggregation that bind the catalytic sites on the surface of the aggregates (KD = 68 nM at pH 4.8 and 13 nM at pH 8.0 (binding to the pocket on the αS fibril)). It works against varies patient-derived fibrils, which is in variance to Anle-138b that accelerated aggregation. I4.05 was discovered by machine learning strategy.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable