SML4221
Ofloxacin hydrochloride
≥98% (HPLC)
别名:
9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hydrochloride, (±)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hydrochloride, Ofloxacin HCl
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
O=C(O)C1=CN2C3=C(OCC2C)C(N4CCN(C)CC4)=C(F)C=C3C1=O.[xHCl]
生化/生理作用
Broad-spectrum fluoroquinolone antibiotic, exhibits water solubility.
Ofloxacin is a fluoroquinolone antibiotic with broad-spectrum activity, which kills bacteria by blocking DNA gyrase and type IV topoisomerase—critical enzymes for DNA replication and transcription—leading to cell death. Ofloxacin has 100 times higher affinity for bacterial DNA gyrase than for mammalian. It is effective against a broad array of both Gram-positive and Gram-negative bacteria, in addition to Mycoplasmas. While the hydrochloride form of ofloxacin is soluble in water, ofloxacin itself is only sparingly soluble in aqueous solutions.
Ofloxacin is a fluoroquinolone antibiotic with broad-spectrum activity, which kills bacteria by blocking DNA gyrase and type IV topoisomerase—critical enzymes for DNA replication and transcription—leading to cell death. Ofloxacin has 100 times higher affinity for bacterial DNA gyrase than for mammalian. It is effective against a broad array of both Gram-positive and Gram-negative bacteria, in addition to Mycoplasmas. While the hydrochloride form of ofloxacin is soluble in water, ofloxacin itself is only sparingly soluble in aqueous solutions.
免责声明
Hygroscopic Store with dessicant
法规信息
新产品
历史批次信息供参考:
Yaping Wu et al.
Journal of global antimicrobial resistance, 36, 13-25 (2023-11-29)
Mycoplasma and Ureaplasma spp. especially M. hominis, U. parvum, and U. urealyticum recognized as an important cause of urogenital infections. Sake of the presence of antibiotic resistance and a continuous rise in resistance, the treatment options are limited, and treatment
Ab Raouf Bhat et al.
International journal of biological macromolecules, 274(Pt 1), 133011-133011 (2024-06-10)
Human serum albumin (HSA) effectively binds to compounds having different molecular weight and thus facilitates their distribution in the living organisms. Thus, the binding interactions between a potential antibacterial drug (levofloxacin) and synthesized choline based levofloxacinate conjugates with HSA have
K Sato et al.
Antimicrobial agents and chemotherapy, 22(4), 548-553 (1982-10-01)
DL-8280, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H- pyrido-(1,2,3-de)1,4-benzoxazine-6-carboxylic acid, is a new nalidixic acid analog with a broad spectrum of antibacterial activity against gram-negative and gram-positive bacteria, including obligate anaerobes. The activity of DL-8280 against Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, and Clostridium perfringens
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