General description
Artepillin C (ARC) is a prenylated derivative of p-coumaric acid. It is one of the primary phenolic compounds present in Brazilian green propolis (BGP) and Baccharis dracunculifolia. It is a p-CA derivative, featuring two prenyl groups linked to the meta-positions (C3 and C5) of the phenyl ring.
Application
Artepillin C may be used to investigate its interaction with human serum albumin (HSA) and to understand its physicochemical transport mechanism in vitro.
Biochem/physiol Actions
Phenolic component of propolis that exhibits multiple activities including anti-inflammatory, anti-tumor, antimicrobial and antioxidant activities; inhibitor of CREB-CRTC2 interaction. The anti-cancer properties of ARC are due to several mechanisms, including the induction of apoptosis, cell cycle arrest, and the inhibition of p21-activated kinase 1 (PAK1).
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
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Yoko Hirata et al.
European journal of pharmacology, 912, 174572-174572 (2021-10-18)
Propolis, a compound produced by honeybees, has long been used in food and beverages to improve health and prevent diseases. We previously reported that the ethanol extracts of Brazilian green propolis and its constituents artepillin C, kaempferide, and kaempferol mitigate
A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex
Chen Y, et al.
Nature Communications, 13, 246-246 (2022)
Núbia Sabrina Martins et al.
Pharmaceutics, 13(11) (2021-11-28)
Propolis is a natural product produced by bees that is primarily used in complementary and alternative medicine and has anti-inflammatory, antibacterial, antiviral, and antitumoral biological properties. Some studies have reported the beneficial effects of propolis in models of allergic asthma.
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