Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
shipped in
wet ice
storage temp.
-10 to -25°C
General description
MTSEA biotin-XX is a membrane-impermeant crosslinker consisting of biotin-coupled 2-aminoethyl-methanethiosulfonate (MTSEA).
Application
MTSEA-Biotin-XX may be used to covalently label cysteine residues in proteins or thiol-containing molecules with a biotin tag for streptavidin-based detection, purification, or accessibility studies and, for biotinylation of 4TU‐labeled RNAs in direct RNA sequencing.
Biochem/physiol Actions
MTSEA-Biotin-XX selectively and efficiently labels cell surface thiols, including cysteine residues and specific RNA modifications (s4U and dm6A), forming disulfide bonds with enhanced reactivity. The extended -XX- linker facilitates optimal biotin-streptavidin interaction, while the overall structure allows for high-yield, rapid reactions. Biotin-XX-MTSEA enables imaging, purification, and sequencing applications through its ability to tag target molecules via methanethiosulfonate (MTS) reactions.
Disclaimer
Hygroscopic, Store with desiccant
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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