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SML4243

Veliparib

Name: Veliparib
Brand: SIGMA

≥98% (HPLC), powder, PARP inhibitor

别名:

2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide, 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide, ABT-888, A 861695, ABT 888

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₆N₄O

化学文摘社编号:

912444-00-9

分子量:

244.29

MDL number:

MFCD16661059

NACRES:

NA.21

Assay:

≥98% (HPLC)

Form:

powder

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属性

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

-10 to -25°C

说明

Application

Veliparib may be used in cell proliferation and colony forming assay to study its effect on O 6-methylguanine methyltransferase (MGMT) unmethylated glioblastoma.

Biochem/physiol Actions

Veliparib (ABT-888) is an orally active, potent and selective poly(ADP-ribose) polymerase (PARP) inhibitor (Ki = 5.2 nM PARP1, and 2.9 nM PARP2) that exhibits potent anti-cancer activity. Veliparib blocks DNA damage repair in cancer cells, additionally rendering them more susceptible for other anti-cancer drugs. As a potent PARP1 and PARP2 inhibitor it induces synthetic lethality in cancer cells.

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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