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关于此项目
经验公式（希尔记法）:
C13H16N4O
化学文摘社编号:
分子量:
244.29
MDL number:
NACRES:
NA.21
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
-10 to -25°C
Application
Veliparib may be used in cell proliferation and colony forming assay to study its effect on O 6-methylguanine methyltransferase (MGMT) unmethylated glioblastoma.
Biochem/physiol Actions
Veliparib (ABT-888) is an orally active, potent and selective poly(ADP-ribose) polymerase (PARP) inhibitor (Ki = 5.2 nM PARP1, and 2.9 nM PARP2) that exhibits potent anti-cancer activity. Veliparib blocks DNA damage repair in cancer cells, additionally rendering them more susceptible for other anti-cancer drugs. As a potent PARP1 and PARP2 inhibitor it induces synthetic lethality in cancer cells.
存储类别
11 - Combustible Solids
闪点 (F)
Not applicable
闪点 (°C)
Not applicable