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SML4245

AT2R agonist C21

Name: AT2R agonist C21
Brand: SIGMA

≥98% (HPLC), angiotensin II receptor agonist, powder

别名:

Buloxibutid, AT2R agonist C 21, AT2R agonist C-21, AT2R agonist compound 21, M 24, M024, Butyl [3-[4-[(1H-imidazol-1-yl)methyl]phenyl]-5-isobutylthiophen-2-yl]sulfonylcarbamate, N-Butyloxycarbonyl-3-[4-(imidazol-1-ylmethyl)phenyl]-5-isobutylthiophene-2-sulfonamide

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关于此项目

经验公式（希尔记法）:

C₂₃H₂₉N₃O₄S₂

化学文摘社编号:

477775-14-7

分子量:

475.62

MDL number:

MFCD26936332

NACRES:

NA.21

Assay:

≥98% (HPLC)

Form:

powder

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属性

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

说明

Application

AT2R agonist C21 may be used to study:

its vasorelaxant effect of C21 in mouse mesenteric arteries derived from wildtype and AT2R-knockout (AT2R-/y) mice
its effects on U46619-induced β-arrestin recruitment to TP-receptors and the effect of C21 on U46619-induced platelet aggregation

Biochem/physiol Actions

C21 (Buloxibutid; Compound 21; M024) is a potent and selective angiotensin II receptor (AT2R) nonpeptide agonist (Ki = 0.4 nM/AT1R vs. >10 µM/AT1R) that induces AT2R-mediated morphological changes in NG 108-15 neuroblastoma-glioma hybrid cells (100 nM for 3 days), blockable by AT2R antagonist PD 123,319 (1 µM). C21 enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats (30 & 300 µg/kg/h via i.v.), and lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats in vivo (50 µg/kg/h via i.v.). C21 shares structural similarities with AT1-receptor antagonists irbesartan and losartan, and may show TP-receptor antagonistic properties.

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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