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SML4249

EPZ020411

≥98% (HPLC)

别名:

EPZ 020411, EPZ-020411, N1,N2-Dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-1,2-ethanediamine (ACI)

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关于此项目

经验公式（希尔记法）:
C25H38N4O3
化学文摘社编号:
1700663-41-7
分子量:
442.59
Assay:
≥98% (HPLC)
Form:
(Oil (syrup))
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Quality Segment

100

assay

≥98% (HPLC)

form

(Oil (syrup))

color

colorless to faint brown

storage temp.

-10 to -25°C

Biochem/physiol Actions

EPZ020411 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC50 = 10 nM; PRMT1/8 IC50 = 119/223 nM). EPZ020411 inhibits PRMT6 expression-induced H3R2 methylation in A375 cells (IC50 = 637 nM), but not PRMT1-specific methylmark (IC50 = 7.1 μM).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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