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SML4255

JNJ-10397049

Name: JNJ-10397049
Brand: SIGMA

≥97% (HPLC), powder, OX2R antagonist

别名:

1-(2,4-Dibromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea, N-(2,4-Dibromophenyl)-N′-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea, JNJ 10397049, JNJ10397049

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₀Br₂N₂O₃

化学文摘社编号:

708275-58-5

分子量:

484.18

MDL number:

MFCD17170315

NACRES:

NA.21

Assay:

≥97% (HPLC)

Form:

powder

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属性

Quality Segment

100

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

说明

Application

JNJ-10397049 may be used in proliferation assay to study its role in growth and differentiation of neural progenitor cells (NPCs).

Biochem/physiol Actions

JNJ-10397049 is a potent and subtype-selective orexin receptor 2 (OX2R) antagonist (pKi = 8.3/OX2R vs. 5.5/OX1R) with little affinity toward a panel of 50 receptors, ion channels and transporters. Blockade of OX2R by JNJ-10397049 antagonizes against orexin B-induced cellular calcium response (pKB = 7.9) and attenuates ethanol self-administration, place preference, and reinstatement in rats in vivo (1, 3, and 10 mg/kg, sc).

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c