Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated, protect from light
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
General description
Ester precursor of the STING(A230/I230)-selective agonist BDW568-OH with no activity toward STING(G230).
BDW568 is an ester precursor of the STING(A230/I230)-selective agonist BDW568-OH with no activity toward STING(G230). Upon entering cells, BDW568 is hydrolyzed by carboxylesterase 1 (CES1) to the active metabolite BDW568-OH, which in turn induces cellular type-I interferon (IFN-I) signaling (EC50 = 7.6 μM by ISRE reporter assay using THP-1 cells, 4.1 μM using STING-/- THP-1 expressing STING with H71, A230, Q293).
BDW568 is an ester precursor of the STING(A230/I230)-selective agonist BDW568-OH with no activity toward STING(G230). Upon entering cells, BDW568 is hydrolyzed by carboxylesterase 1 (CES1) to the active metabolite BDW568-OH, which in turn induces cellular type-I interferon (IFN-I) signaling (EC50 = 7.6 μM by ISRE reporter assay using THP-1 cells, 4.1 μM using STING-/- THP-1 expressing STING with H71, A230, Q293).
Disclaimer
Hygroscopic Store with dessicant
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Irrit. 2
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable