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Assay:
≥95% (HPLC)
Form:
(Powder or Lyophilized powder or film)
Quality level:
Storage condition:
desiccated
assay
≥95% (HPLC)
form
(Powder or Lyophilized powder or film)
storage condition
desiccated
color
white to off-white
storage temp.
-10 to -25°C
Quality Level
General description
Cell-permeable phosphatidylinositol 3-kinase (PI 3-kinase, PI3K) activator.
740 Y-P is a cell-permeable phosphatidylinositol 3-kinase (PI 3-kinase, PI3K) activator composed of the Drosophila antennapedia-derived membrane-permeant 16-mer sequence RQIKIWFQNRRMKWKK followed by a phosphotyrosine-containing, PDGFR-derived sequence SDGGY(P)MDMS that targets SH2 domains of PI3K p85 regulatory subunit. When applied to serum-starved C2 cells at 50 µg/mL, 740 Y-P is more effective than 10% FCS, 5 ng/mL bFGF or 10 ng/mL EGF in stimulating cell proliferation (% of cells in S-phase post 48h stimulation = 48.3, 42.5, 35.7 and 32.8, respectively). 740 Y-P-induced mitogenic response is blocked by wortmannin or rapamycin, but not MEK inhibitor PD98058.
740 Y-P is a cell-permeable phosphatidylinositol 3-kinase (PI 3-kinase, PI3K) activator composed of the Drosophila antennapedia-derived membrane-permeant 16-mer sequence RQIKIWFQNRRMKWKK followed by a phosphotyrosine-containing, PDGFR-derived sequence SDGGY(P)MDMS that targets SH2 domains of PI3K p85 regulatory subunit. When applied to serum-starved C2 cells at 50 µg/mL, 740 Y-P is more effective than 10% FCS, 5 ng/mL bFGF or 10 ng/mL EGF in stimulating cell proliferation (% of cells in S-phase post 48h stimulation = 48.3, 42.5, 35.7 and 32.8, respectively). 740 Y-P-induced mitogenic response is blocked by wortmannin or rapamycin, but not MEK inhibitor PD98058.
Disclaimer
Hygroscopic Store with desiccant
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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