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SML4284

Fumarate hydratase-IN-1

≥98% (HPLC), powder, fumarate hydratase inhibitor

别名:

rel- Ethyl (3S,3aR)-1-([1,1′-biphenyl]-4-ylmethyl)-3-(2-(methylamino)-2-oxoethyl)-2-oxo-1,2,3,4,5,6-hexahydro-3aH-indole-3a-carboxylate

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关于此项目

经验公式（希尔记法）:
C27H30N2O4
化学文摘社编号:
1644060-37-6
分子量:
446.54
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Application

Fumarate hydratase-IN-1 may be used:

  • to study its effects on mitochondrial bioenergetics and macrophage metabolism
  • to assess its regulatory effects in LPS-induced acute lung injury (ALI) models
  • to study the role of fumarate in immunomodulation and regulating type I interferon production after viral infection

Biochem/physiol Actions

FHIN1 exhibits nutrient-dependent antiproliferation activity in cancer cultures (mean IC50 = 2.2 µM in glucose-free L-15 medium; SW620, ACHN, HCT-116, PC3, SK-MEL-28) by targeting tricarboxylic acid (TCA) cycle without blocking mitochondrial electron-transport chain (ETC) or ATP synthase.

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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