SML4312

eIF4A3-IN-1

Name: eIF4A3-IN-1
Brand: SIGMA

≥97% (HPLC)

别名:

3-[4-[[(3S)-4-(4-Bromobenzoyl)-3-(4-chlorophenyl)-1-piperazinyl]carbonyl]-5-methyl-1H-pyrazol-1-yl]benzonitrile, Compound 53a

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关于此项目

经验公式（希尔记法）:

C₂₉H₂₃BrClN₅O₂

化学文摘社编号:

2095486-67-0

分子量:

588.88

UNSPSC Code:

12352200

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

100

主要文件

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assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

eIF4A3-IN-1 (Compound 53a) is a highly selective, cell-active inhibitor of eukaryotic initiation factor 4A3 (eIF4A3), exhibiting an ATPase IC50 of 0.26 µM and a KD of 0.043 µM. By directly binding a non-ATP site on eIF4A3, eIF4A3-IN-1 inhibits RNA-dependent ATPase activity while demonstrating excellent selectivity over related helicases eIF4A1, eIF4A2, DHX29, and BRR2 (all IC50 >100 µM). This targeted inhibition subsequently causes dose-dependent cellular suppression of nonsense-mediated RNA decay (NMD), affecting the stability of mRNAs with premature termination codons.