Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
MN551 is an E3 ligase suppressor of cytokine signaling 2 (SOCS2) inhibitor that blocks SOCS2 substrate binding by covalently modifying SOCS2 SH2 domain EF loop Cys111. MN551 also effectively modifies SH2 containing protein (CISH) (Cys114), but not SOCS4 (Cys350) or SOCS6 (no EF loop Cys). Preincubation of K562 lysate with MN551 (1.5h at r.t.) blocks endogenous SOCS2 from binding immobilized GHR pY595 substrate peptide (IC50 = 5.9 µM).
Disclaimer
Hygroscopic Store with desiccant
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable