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SML4364

AMXT1501 tetrahydrochloride

≥98% (HPLC)

别名:

(R)-N-(5-amino-6-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-6-oxohexyl)palmitamide tetrahydrochloride, D-Lys(C16acyl)-Spm 4HC, AMXT 1501 4HC, AMXT-1501 4HCl

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关于此项目

经验公式（希尔记法）:
C32H68N6O2·4HCl
化学文摘社编号:
2444815-84-1
分子量:
714.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

-10 to -25°C

Biochem/physiol Actions

AMXT1501 is a lipophilic polyamine analog that acts as a potent polyamine transport inhibitor. When combined with the polyamine biosynthesis inhibitor DFMO, AMXT1501 potently inhibits cell growth in cancer cultures (GI50 in nM in the presence of 5 mM DFMO, 500 nM spermidine & 1 mM aminoguanidine = 76/MDA-231, 120/PC-3, 31/A375, 170/SK-OV-3) and induces complete or nearly complete remission of cutaneous squamous cell carcinomas (SCC) growth in a transgenic ornithine decarboxylase (ODC) mouse model of skin cancer in vivo (0.5-0.7 mg/kg via b.i.d. i.p. with DFMO at 0.5% in drinking water).

Disclaimer

Hygroscopic, store with desiccant

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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