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关于此项目
经验公式（希尔记法）:
C38H36F6N6O4·C4H6O4
化学文摘社编号:
分子量:
872.81
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
drug control
USDEA Schedule V
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Lasmiditan (COL-144 and LY573144) is an orally active, potent and selective high-affinity serotonin receptor 5-HT1F agonist (5-HT1F/1E Ki = 2.21/594 nM; 5-HT1A/B/C Ki >1 μM; 5-HT2A/B/C Ki >2 μM; 5-HT6/7 Ki >3 μM). Lasmiditan induces mitochondrial biogenesis (MB) in human glomerular endothelial cells and mouse glomerular endothelial cells (100 nM for 72h). Unlike the triptans, Lasmiditan is void of vasoconstrictor activity toward isolated human coronary arteries (up to 100 μM) or in anaesthetized female beagle dogs in vivo (4.13-11.13 mg/kg i.v.)
Disclaimer
Hygroscopic, Store with desiccant
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2 - STOT SE 3
target_organs
Central nervous system
存储类别
11 - Combustible Solids