Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
MSC-1186 (MSC2711186) is a potent and selective (SR)-rich splicing factor (SRSF) protein kinases (serine-arginine protein kinases) inhibitor (SRPK1/2/3 IC50 = 2.7/81/0.59 nM; SRPK2 Kd = 145 nM by ITC; selectivity assessed at 1 µM against 395 Kinases) with high cellular potency (SRPK1/3 IC50 = 98/40 nM by whole cell NanoBRET assay) and no activity towards CLKs or DYRKs (IC50 >10 µM).
存储类别
11 - Combustible Solids
闪点 (F)
Not applicable
闪点 (°C)
Not applicable