5-TAMRA-PEG4-Alkyne

5-TAMRA-PEG4-Alkyne (TAMRA-PEG4-Alkyne) is a high-precision bioorthogonal probe engineered for the specific, covalent labeling of azide-modified biomolecules. TAMRA-Alkyne integrates the bright, photostable 5-TAMRA fluorophore (λex/λem: ~555/580 nm) with a terminal alkyne for irreversible copper-catalyzed click chemistry. Its key strategic advantage lies in the bifunctional design, where an isomerically pure fluorophore ensures reproducibility and a hydrophilic PEG4 linker enhances aqueous solubility while minimizing non-specific background. This construct enables robust, high signal-to-noise visualization of metabolically incorporated tags in complex biological samples via microscopy and in-gel analysis, providing a versatile and reliable alternative to antibody-based detection methods for studying dynamic cellular processes.

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