Lithocholic acid High Purity

Lithocholic acid (LCA), a secondary bile acid absorbed into the bloodstream and transported to muscle, acts as a TGR5 agonist and endogenous calorie restriction mediator, indirectly activating SIRT1 via TUB Like Protein 3 (TULP3) to engage AMPK through v-ATPase inhibition. This cascade improves metabolic parameters and stress resistance, raises GLP-1, and notably exhibits antineoplastic effects in pancreatic adenocarcinoma by inducing oxidative/nitrosative stress via CAR, FXR, and VDR nuclear receptors, inhibiting proliferation, EMT, and stem cell markers while upregulating mitochondrial oxidative phosphorylation. LCA extends lifespan in model organisms and enhances grip strength and insulin sensitivity in aged mice, underscoring its broad therapeutic potential in aging and oncology.