Merck
CN

SRE0006

Sigma-Aldrich

胸苷磷酸化酶,重组 来源于大肠杆菌

recombinant, expressed in E. coli, Suitable for manufacturing of diagnostic kits and reagents, buffered aqueous solution, ≥500 units/mL

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别名:
胸苷:正磷酸脱氧-D-核糖基转移酶
CAS号:
MDL编号:
NACRES:
NA.54

重组

expressed in E. coli

质量水平

形式

buffered aqueous solution

浓度

≥500 units/mL

application(s)

diagnostic assay manufacturing

运输

wet ice

储存温度

2-8°C

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此商品
T6632T2807SRE0005
form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

concentration

≥500 units/mL

concentration

≥900 units/mL

concentration

≥500 units/mL

concentration

≥10 mg/mL protein, ≥800 unit/mL

application(s)

diagnostic assay manufacturing

application(s)

-

application(s)

-

application(s)

diagnostic assay manufacturing

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

wet ice

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

一般描述

Research area: CELL SIGNALING

The E. coli thymidine phosphorylase shares 40% sequence homology with the human sequence, which is identical to the angiogenic agent platelet-derived endothelial growth factor. The purified E. coli enzyme has been shown to stimulate blood vessel growth in chick chorioallantoic membrane assays.

应用

Thymidine phosphorylase has been used:
  • in a study to evaluate biomarkers for advanced breast cancer patients treated with capecitabine-based first-line chemotherapy.
  • in a study to investigate implications for the clinical efficacy of nucleoside analogues.

生化/生理作用

一种对胸腺嘧啶可逆性转化为胸腺嘧啶进行催化的酶。胸苷磷酸化酶是嘧啶核苷挽救途径的一部分。该途径允许嘧啶碱基被回收用于核苷酸生物合成,而1-磷酸戊糖被转化为磷酸戊糖分流和糖酵解的中间体。 大肠埃希菌胸苷磷酸化酶与人序列具有40%的序列同源性,已发现该序列与血管生成剂血小板衍生的内皮生长因子相同。 在鸡绒膜尿囊膜测定中,纯化的大肠埃希菌酶已显示出刺激血管生长的作用。
Thymidine phosphorylase catalyzes the reversible conversion of thymidine to thymine. Thymidine phosphorylase is part of the thymidine salvage pathway and pyrimidine nucleoside salvage pathway. This pathway allows pyrimidine bases to be recycled for nucleotide biosynthesis, while the pentose 1-phosphates are converted to intermediates of the pentose phosphate shunt and glycolysis. The enzyme inhibits apoptosis and induces angiogenesis thereby promoting tumor growth and metastatic process. Moreover, thymidine phosphorylase inhibits vascular smooth muscle cell proliferation.

单位定义

One unit will convert 1.0 μmole each of thymidine and phosphate to thymine and 2-deoxyribose 1-phosphate per min at pH 7.4 at 25°C.

制备说明

Cloned from E. coli and produced in overexpressing E. coli

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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The dual role of thymidine phosphorylase in cancer development and chemotherapy
Bronckaers A, et al.
Medicinal Research Reviews, 29(6), 903-953 (2009)
Thymidine kinase 1 and thymidine phosphorylase expression in non-small-cell lung carcinoma in relation to angiogenesis and proliferation
Brockenbrough J S, et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 57(11), 1087-1097 (2009)
Structures of native human thymidine phosphorylase and in complex with 5-iodouracil
Mitsiki E, et al.
Biochemical and Biophysical Research Communications, 386(4), 666-670 (2009)
Hriday Bera et al.
European journal of medicinal chemistry, 67, 325-334 (2013-07-23)
Thirty-three 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues were designed and synthesized which contained different substituents at meta- and/or para-positions of 2-phenyl or 2-benzyl ring attached to the fused ring structure. The preliminary pharmacological evaluation demonstrated that the 5-thioxo analogues of 1,2,4-triazolo[1,5-a][1,3,5]triazine
Jen-Chung Ko et al.
Biochemical pharmacology, 88(1), 119-127 (2014-01-23)
Tamoxifen is a triphenylethylene nonsteroidal estrogen receptor (ER) antagonist used worldwide as an adjuvant hormone therapeutic agent in the treatment of breast cancer. However, the molecular mechanism of tamoxifen-induced cytotoxicity in non-small cell lung cancer (NSCLC) cells has not been

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