SRE0011
γ-球蛋白 来源于牛血液
Suitable for manufacturing of diagnostic kits and reagents, ≥99% (agarose gel electrophoresis)
别名:
牛 γ-球蛋白
General description
富含抗体的血浆蛋白组分
牛丙种球蛋白（BGG）是奶牛和其他牛类免疫系统的重要组成部分。BGG 存在于牛的血液中，主要用于生产疫苗、血清和诊断试剂等医疗制品。BGG 还可用于治疗乙肝等疾病，以及增强人类和其他动物的免疫力。
γ-Globulins are immunoglobulins that contain IgM, IgA, and IgY. They are glycoproteins produced by plasma cells. The immunoglobulins are heterodimeric molecules comprising two light chains and two heavy chains linked together by disulfide bonds.
Application
牛γ-球蛋白已被用作免疫耐受机制研究中的一种免疫应激。
γ-Globulins from bovine blood has been used along with polyethylene glycol (PEG) to investigate the kinetics of liquid-liquid phase separation (LLPS) in its temporary and arrested state. It has also been used as a parent solution to prevent bacterial growth and study the antibody system with LLPS and highly elevated protein concentrations in arrested transition.
Biochem/physiol Actions
Immunoglobulins are implicated in the activation of the complement system and the opsonization of microbes for phagocytosis. It is also involved in the neutralization of toxins and viruses and blocks the attachment of microbes to mucosal surfaces. They protect our bodies against fungi, viruses, and bacteria. Immunodeficiency is associated with recurrent infectious diseases.
Preparation Note
由 Cohn 组分 II、III 制备
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Blood
Sturkie's Avian Physiology, 167-191, 167-191 (2015)
Stefano Da Vela et al.
Soft matter, 13(46), 8756-8765 (2017-11-14)
We investigate the transition of the phase separation kinetics from a complete to an arrested liquid-liquid phase separation (LLPS) in mixtures of bovine γ-globulin with polyethylene glycol (PEG). The solutions feature LLPS with upper critical solution temperature phase behavior. At
Justiz Vaillant AA, et al.
Immunoglobulin (2021)
Anita Girelli et al.
Molecular pharmaceutics, 18(11), 4162-4169 (2021-10-13)
Antibody therapies are typically based on high-concentration formulations that need to be administered subcutaneously. These conditions induce several challenges, inter alia a viscosity suitable for injection, sufficient solution stability, and preservation of molecular function. To obtain systematic insights into the
Harry W Schroeder et al.
The Journal of allergy and clinical immunology, 125(2 Suppl 2), S41-S52 (2010-03-05)
Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains. They can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.
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