Merck
CN

SRE0037

Sigma-Aldrich

β-葡萄糖醛酸酶

aqueous solution, β-glucuronidase ≥100,000 units/mL

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形式

aqueous solution

质量水平

β-glucuronidase activity

≥100,000 units/mL

secondary activity

≤8,000 units/mL sulfatase

储存温度

2-8°C

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此商品
SRE0023SRE0103SRE0093
β-Glucuronidase from abalone aqueous solution, β-glucuronidase ≥100,000 units/mL

Sigma-Aldrich

SRE0037

β-葡萄糖醛酸酶

β-Glucuronidase from abalone Purified, aqueous solution, β-glucuronidase 150,000-250,000 units/mL, β-glucuronidase ≥20,000,000 units/g protein

Sigma-Aldrich

SRE0023

β-葡萄糖醛酸酶

MS β-Glucuronidase Prebuffered, automation-ready hydrolysis mix

Sigma-Aldrich

SRE0103

MS β-Glucuronidase

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

β-glucuronidase activity

≥100,000 units/mL

β-glucuronidase activity

≥20,000,000 units/g protein, 150,000-250,000 units/mL

β-glucuronidase activity

-

β-glucuronidase activity

-

secondary activity

≤8,000 units/mL sulfatase

secondary activity

≤7,500 units/mL sulfatase

secondary activity

-

secondary activity

-

应用

来自鲍鱼的β-葡糖苷酸已用作标准品,用于评估其在苯并二氮卓(benzodiazepine)液相色谱-质谱(LC-MS/MS)验证测试中的性能。
比较不同酶性能的新技术文章
了解更多
关于Sigma R&D生成的最新应用数据以便使用不同来源的酶优化不同药物类别的水解,并使用色谱纯化酶降低酯酶活性的影响,导致6-MAM转化为吗啡

生化/生理作用

β-葡糖醛酸糖苷酶是存在于多种动物、植物和细菌中的酶。它催化β-葡糖苷酸偶联物和植物葡糖苷酸的水解。β-葡糖醛酸糖苷酶是糖基水解酶(GH)家族2的一员,也是一种同型四聚体糖蛋白。它促进葡糖苷酸上葡糖醛酸的去除,并有助于肝脏代谢酶排泄内源和外来物质。

单位定义

在37℃,pH 3.8(30分钟检测)条件下,一个Sigma或改良的Fishman单位可每小时从酚酞葡糖苷酸中释放1.0 μg酚酞。

外形

以含有0.85%NaCl和0.02%叠氮化钠的水溶液形式提供

象形图

Health hazard

警示用语:

Danger

危险声明

预防措施声明

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Francesco Candeliere et al.
Frontiers in microbiology, 13, 826994-826994 (2022-03-22)
β-glucuronidases (GUS) of intestinal bacteria remove glucuronic acid from glucoronides, reversing phase II metabolism of the liver and affecting the level of active deconjugated metabolites deriving from drugs or xenobiotics. Two hundred seventy-nine non-redundant GUS sequences are known in the
D H Kim et al.
Biological & pharmaceutical bulletin, 22(2), 162-164 (1999-03-17)
To prove the relationship between the fluctuation in serum beta-glucuronidase level and hepatotoxicity, an inhibitor of beta-glucuronidase from G. lucidum was isolated and its hepatoprotective activity was investigated. The ether fraction of G. lucidum, which had potent beta-glucuronidase-inhibitory activity, protected
Miau-Guo Kang et al.
Journal of analytical toxicology, 43(2), 96-103 (2018-10-03)
Benzodiazepines is a large drug group used extensively to treat sleep disorders and anxiety; these drugs are frequently associated with various crimes such as murder and drug-facilitated sexual assault. With growing use and misuse of these compounds, confirmatory assays are
Paul Awolade et al.
European journal of medicinal chemistry, 187, 111921-111921 (2019-12-14)
The emergence of disease and dearth of effective pharmacological agents on most therapeutic fronts, constitutes a major threat to global public health and man's existence. Consequently, this has created an exigency in the search for new drugs with improved clinical

商品

Evaluation of Different Enzymes on Hydrolysis Efficiencies of Glucuronide Drug Metabolites in Urine

β-glucuronidase (GUS) enzymes are utilized to hydrolyze glucuronide (gluc) drug metabolites to the parent drug, facilitating analysis by LC-MS/MS.

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