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SRP0330

BTK active human

Name: BTK active human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

别名:

AGMX1, BPK, Bruton agammaglobulinemia tyrosine kinase, PSCTK1

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关于此项目

化学文摘社编号:

391968-46-0

NACRES:

NA.32

UNSPSC Code:

12352204

Assay:

≥80% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in baculovirus infected Sf9 cells

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属性

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥80% (SDS-PAGE)

form

aqueous solution

mol wt

106 kDa

packaging

pkg of 10 μg

technique(s)

activity assay: suitable, inhibition assay: suitable

NCBI accession no.

NM_000061

UniProt accession no.

Q06187

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... BTK(695)

说明

General description

Human BTK (GenBank Accession No. NM_000061), full length with N-terminal GST-tag, MW= 106 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

4040500106

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Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages.

M Liljeroos et al.

Cellular signalling, 19(3), 625-633 (2006-10-06)

Lipoteichoic acid (LTA) of Gram-positive bacteria initiates innate immune responses via Toll-like receptor-2 (TLR2), resulting in the activation of intracellular signaling and production of inflammatory cytokines in macrophages. Although Bruton's tyrosine kinase (Btk) is biologically important molecule implicated in immune

Characterization of a Novel Alkalophilic Lipase From Aneurinibacillus thermoaerophilus: Lid Heterogeneity and Assignment to Family I.5.

Ximena Zottig et al.

The protein journal, 36(6), 478-488 (2017-10-05)

Recent investigations of Aneurinibacillus thermoaerophilus strains have allowed identification of a unique solvent tolerant lipase, distinct from known lipases. This work reports the expression and purification of this lipase (LipAT) and the first characterization of its structure and temperature and

A High-Throughput BRET Cellular Target Engagement Assay Links Biochemical to Cellular Activity for Bruton's Tyrosine Kinase.

L L Ong et al.

SLAS discovery : advancing life sciences R & D, 25(2), 176-185 (2019-11-12)

Protein kinases are intensely studied mediators of cellular signaling. While traditional biochemical screens are capable of identifying compounds that modulate kinase activity, these assays are limited in their capability of predicting compound behavior in a cellular environment. Here, we aim

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全球贸易项目编号

货号	GTIN
SRP0330-10UG	04061837195464