生物来源
rat
重组
expressed in baculovirus infected Sf9 cells
方案
≥58% (SDS-PAGE)
表单
aqueous solution
分子量
57 kDa
包装
pkg of 10 μg
技术
activity assay: suitable
inhibition assay: suitable
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
rat ... Itk(363577)
一般描述
Rat recombinant IL2-inducible T-cell kinase (ITK), also known as Lyk and TSK (GenBank AccessionNo. NM_001108825), amino acids 352-620 (end) with N-terminal GST-tag, MW= 57 kDa, expressed in Sf9 cells via a Baculovirus expression system.
应用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
N Tanaka et al.
FEBS letters, 324(1), 1-5 (1993-06-07)
We have cloned a novel human protein tyrosine kinase gene specific to T cells by the polymerase chain reaction method. This gene encodes a 620 amino-acid polypeptide including a catalytic domain for tyrosine kinase, an SH2 domain and an SH3
Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity.
J Hawkins et al.
Protein expression and purification, 22(2), 211-219 (2001-07-05)
Itk is a Tec family tyrosine kinase found in T cells that is activated upon ligation of the T cell receptor (TCR/CD3), CD2, or CD28. Itk contains five domains in addition to the catalytic domain: pleckstrin homology, Tec homology which
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