SRP0344
EGFR active mouse
recombinant, expressed in baculovirus infected Sf9 cells
别名:
ERBB, ERRP, Wa5, epidermal growth factor receptor
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
aqueous solution
Biological source:
mouse
Recombinant:
expressed in baculovirus infected Sf9 cells
Mol wt:
62 kDa
产品名称
EGFR active mouse, recombinant, expressed in baculovirus infected Sf9 cells
biological source
mouse
recombinant
expressed in baculovirus infected Sf9 cells
form
aqueous solution
mol wt
62 kDa
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
mouse ... EGFR(13649)
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
General description
Mouse EGFR (GenBank Accession No. NM_207655/ NP_997538), amino acids 670-1210 with C-terminal Flag-tag, MW = 62 kDa, expressed in SF9 cells via a Baculovirus expression system.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Ariel Talavera et al.
Molecular immunology, 48(12-13), 1578-1585 (2011-05-20)
The EGF receptor is an important target of cancer immunotherapies. The 7A7 monoclonal antibody has been raised against the murine EGFR, but it cross-reacts with the human receptor. The results from experiments using immune-competent mice can therefore, in principle, be
Jeffrey D Kearns et al.
Molecular cancer therapeutics, 14(7), 1625-1636 (2015-04-26)
Although EGFR is a validated therapeutic target across multiple cancer indications, the often modest clinical responses to current anti-EGFR agents suggest the need for improved therapeutics. Here, we demonstrate that signal amplification driven by high-affinity EGFR ligands limits the capacity
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