SRP0349
Flt3 active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)
别名:
CD135, FLK2, STK1, fms-related tyrosine kinase 3
生物来源
human
重组
expressed in baculovirus infected Sf9 cells
方案
≥80% (SDS-PAGE)
表单
aqueous solution
分子量
54.2 kDa
包装
pkg of 10 μg
技术
activity assay: suitable
inhibition assay: suitable
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... FLT3(2322)
一般描述
Human Flt3 (GenBank Accession No. NM_004119), amino acids 564-end with N-terminal His-tag, MW=54.2 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
应用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
警示用语：
Danger
危险声明
危险分类
Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
Connor P Hall et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 22(3), 621-632 (2015-06-18)
The aim of our study is to evaluate the preclinical therapeutic activity and mechanism of action of BEZ235, a dual PI3K/mTOR inhibitor, in combination with dexamethasone in acute lymphoblastic leukemia (ALL). The cytotoxic effects of BEZ235 and dexamethasone as single
Mark Levis et al.
Blood, 106(2), 673-680 (2005-03-31)
Internal tandem duplication mutations of the FLT3 gene (FLT3/ITD mutations) are the most frequent molecular abnormality in acute myeloid leukemia (AML) and are associated with a poor overall survival. While the normal FLT3 receptor is expressed in early hematopoietic progenitor
Shinichiro Takahashi et al.
Leukemia research, 29(8), 893-899 (2005-06-28)
Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B
Amanda Lance et al.
Leukemia, 34(2), 369-379 (2019-08-30)
Three annotated CSF3R mRNA splice variants have been described. CSF3R-V1 is the wild-type receptor, while CSF3R-V4 is a truncated form increased in some patients with AML. CSF3R-V3 mRNA was identified in placenta more than 20 years ago, but remains largely
Ophir Shani et al.
Cancer research, 80(23), 5317-5329 (2020-10-08)
Lungs are one of the main sites of breast cancer metastasis. The metastatic microenvironment is essential to facilitate growth of disseminated tumor cells. Cancer-associated fibroblasts (CAF) are prominent players in the microenvironment of breast cancer. However, their role in the
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