SRP0353
Akt1 active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE)
别名:
PKB, RAC, v-akt murine thymoma viral oncogene homolog 1
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352202
Assay:
≥75% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥75% (SDS-PAGE)
form
aqueous solution
mol wt
60.2 kDa
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... AKT1(207)
General description
AKT1 (v-akt murine thymoma viral oncogene homolog 1) is a Ser/Thr protein kinase, and is also called protein kinase B (PKB). This protein is activated when it is phosphorylated at serine 473 and threonine 308. This gene is localized to human chromosome 14q32.32.
Application
Akt1 active human has been used for the testing of recombinant mouse p21 proteins as its substrates using in vitro protein kinase assay.
Biochem/physiol Actions
AKT1 (v-akt murine thymoma viral oncogene homolog 1) is responsible for the phosphorylation and cytoplasmic localization of CKDN1A (cyclin-dependent kinase (CDK) inhibitor 1, also referred to as p21). However, p21 is one of the CDKNs which normally resides in the nucleus and its cytoplasmic localization, mediated by AKT1, is common to various cancers where it suppresses proteins essential for apoptosis. Studies show that up-regulation of AKT1 serves as a poor prognostic marker in breast cancer, which however, depends upon factors including population, hormone receptor status, and hormonal or trastuzumab therapy status.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable