assay
≥90% (HPLC)
form
aqueous solution
packaging
pkg of 80 nmol
concentration
400 μM
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CARM1(10498)
General description
Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2.
Application
Study enzyme kinetics, and screen small molecular inhibitors of PRMT4 histone methyltransferase for drug discovery and HTS applications.
Biochem/physiol Actions
Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2a, a chromatin remodeler. It also associates with nuclear factor-κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers.
Physical form
Supplied in a TRIS-buffered solution.
Other Notes
200 μL at 400 μM, or 80 nmol. Sold as 80 nmol
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable