Histone cluster 2 H2A family member c (HIST2H2AC) is located on human chromosome 1q21. It is usually present in undifferentiated/proliferating cells. This canonical histone isoform has a protruding tail at both the N- and C-termini.

Histones make up the nucleosome, which is the fundamental unit of the chromatin. Each nucleosome consists of 146 base pairs of DNA which is wrapped around an octamer of four core histones H2A, H2B, H3 and H4. Histone cluster 2 H2A family member c (HIST2H2AC) has many variants. Human Histone 2A (GenBank Accession No. NM_033445) amino acids 2-130 (end) with N-terminal His-tag, MW = 14.8 kDa, expressed in an E. coli expression system.

Histone cluster 2 H2A family member c (HIST2H2AC) has a role in maintaining the structure of the chromatin.

Histone cluster 2 H2A family member c (HIST2H2AC) participates in multiple epigenetic regulations and carcinogenesis. It also participates in embryonic stem (ES) cell biology and regulates the expression of genes. It modulates proliferation and epithelial-mesenchymal transition in mammary epithelial and breast cancer cells. Hist2h2ac also controls epithelial differentiation.