SRP0438
TDP2 active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥87% (SDS-PAGE)
别名:
EAP2, TTRAP, tyrosyl-DNA phosphodiesterase 2
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
aqueous solution
Assay:
≥87% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells
Mol wt:
67 kDa
产品名称
TDP2 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥87% (SDS-PAGE)
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥87% (SDS-PAGE)
form
aqueous solution
mol wt
67 kDa
packaging
pkg of 20 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... TDP2(51567)
General description
Human tyrosyl DNA phosphodiesterase 2, or TDP2 (GenBank Accession No. NM_016614) full length with N-terminal His-GST-tag, MW = 67 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Physical form
Formulated in 40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 200 mM Imidazole, 20% Glycerol, and 3 mM DTT.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Ka Cheong Lee et al.
International journal of molecular sciences, 19(7) (2018-07-18)
DNA topoisomerase II (TOP2) activity involves a normally transient double-strand break intermediate in which the enzyme is coupled to DNA via a 5'-phosphotyrosyl bond. However, etoposide and other topoisomerase drugs poison the enzyme by stabilising this enzyme-bridged break, resulting in
Christophe Marchand et al.
Molecular cancer therapeutics, 13(8), 2116-2126 (2014-07-16)
Drug screening against novel targets is warranted to generate biochemical probes and new therapeutic drug leads. TDP1 and TDP2 are two DNA repair enzymes that have yet to be successfully targeted. TDP1 repairs topoisomerase I-, alkylation-, and chain terminator-induced DNA
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