生物来源
human
重组
expressed in baculovirus infected Sf9 cells
方案
≥20% (SDS-PAGE)
表单
aqueous solution
分子量
90.5 kDa
包装
pkg of 50 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... TNFAIP3(7128)
一般描述
人A20，也称为肿瘤坏死因子α诱导蛋白3（TNFAIP3）或含有OTU结构域的蛋白7C（OTUD7C），（GenBank登录号NM_006290）氨基酸2-791（末端），带有N-末端标记标签，MW=90.5 kDa，通过杆状病毒表达系统在Sf9昆虫细胞中表达。
应用
可用于研究酶动力学、抑制剂筛选和选择性分析。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
Sarah G Hymowitz et al.
Nature reviews. Cancer, 10(5), 332-341 (2010-04-13)
Clinicians have suspected for hundreds of years that chronic activation of the immune system contributes to the development of cancer. However, the molecular mechanisms that mediate this precarious interplay are only now being elucidated. Recent reports have identified A20 as
Jing Liu et al.
Journal of biomedical science, 20, 74-74 (2013-10-09)
Intestinal polyps may further develop into colon cancer; the pathogenesis is not clear. The p53 gene is an important anti-cancer gene in the body, which is suppressed in cancer. The ubiquitin E3 ligase A20 (A20) plays a role in regulating
Chong-Shan Shi et al.
Autophagy, 6(7), 986-987 (2010-08-28)
Toll-like receptor 4 (TLR4) signaling triggers autophagy, which has been linked to both adaptive and innate immunity. Engagement of TLR4 recruits to the receptor complex Beclin 1, a key component of a class III phosphatidylinositol 3-kinase complex (PI3KC3) that initiates
Rita M Tavares et al.
Immunity, 33(2), 181-191 (2010-08-14)
A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against tumor necrosis factor (TNF)-induced programmed cell death. Given recent data linking A20 (TNFAIP3) with human B cell lymphomas and systemic lupus erythematosus (SLE), we have generated
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