SRP0446
RNF20 active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥50% (SDS-PAGE)
别名:
BRE1, BRE1A, hBRE1, ring finger protein 20, E3 ubiquitin protein ligase
产品名称
RNF20 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥50% (SDS-PAGE)
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥50% (SDS-PAGE)
form
aqueous solution
mol wt
115 kDa
packaging
pkg of 20 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... RNF20(56254)
General description
Human ring finger protein 20, or RNF20 (GenBank Accession No. NM_019592) full length, amino acids 2-975 (end) with N-terminal His-Flag-tag, MW=115 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Physical form
Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/uL Flag peptide, 20% glycerol and 3 mM DTT.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Efrat Shema et al.
Molecular cell, 42(4), 477-488 (2011-05-21)
hBRE1/RNF20 is the major E3 ubiquitin ligase for histone H2B. RNF20 depletion causes a global reduction of monoubiquitylated H2B (H2Bub) levels and augments the expression of growth-promoting, pro-oncogenic genes. Those genes reside preferentially in compact chromatin and are inefficiently transcribed
Yosef Shiloh et al.
FEBS letters, 585(18), 2795-2802 (2011-08-11)
The DNA damage response (DDR) is emerging as a vast signaling network that temporarily modulates numerous aspects of cellular metabolism in the face of DNA lesions, especially critical ones such as the double strand break (DSB). The DDR involves extensive
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