assay
>95% (HPLC)
form
lyophilized powder
mol wt
~445.4
shipped in
ambient
storage temp.
−20°C
Biochem/physiol Actions
A selective inhibitor of the p70 ribosomal S6 kinase (S6K). Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 uM with no activity at GSK3beta and Erk1/2 at 10 uM (2). Useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K. Cell permeable.
Preparation Note
Formulated as a lyophilized powder. May be dissolved in DMSO (1 mg/mL) or DMF (3 mg/mL, warm).
Store desiccated as supplied at -20°C for up to 3 years. Store solutions at -20°C for up to 3 months.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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