SRP2042
LXRα-ligand binding domain (215-667) human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
别名:
LXR-a, LXRA, RLD-1
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关于此项目
NACRES:
NA.26
UNSPSC Code:
12352200
Form:
frozen liquid
Assay:
≥70% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
~30.6 kDa
biological source
human
recombinant
expressed in E. coli
assay
≥70% (SDS-PAGE)
form
frozen liquid
mol wt
~30.6 kDa
packaging
pkg of 10 μg
concentration
300 μg/mL
color
clear colorless
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... NR1H3(10062)
Biochem/physiol Actions
Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXR α and LXR β. LXRa is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXR β expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). The ligand binding domain (LBD) of LXR determines ligand specificity and mediates the trans-activation function of the receptor.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable