产品名称
TFIIA (p12), γ subunit, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
biological source
human
recombinant
expressed in E. coli
assay
≥70% (SDS-PAGE)
form
frozen liquid
mol wt
~40 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
color
clear colorless
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... GTF2A2(2958)
Biochem/physiol Actions
p12 is a small subunit γ of the transcription factor IIA and has been shown to be required for both basal and activated transcription. Recombinant p12, along with two other subunits (α and β) can potentiate transcriptional activation, whereas p12 along with a β subunit is able to function in an anti-repression.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
X Sun et al.
Genes & development, 8(19), 2336-2348 (1994-10-01)
Human TFIIA activity is composed of three subunits (alpha, beta, gamma). Here we report the isolation of a human cDNA clone encoding the gamma-subunit and the reconstitution of TFIIA activity from recombinant polypeptides (holo-TFIIA). Protein-protein interaction analysis established that the
J Ozer et al.
Genes & development, 8(19), 2324-2335 (1994-10-01)
TFIIA is thought to play an important role in transcriptional regulation in higher eukaryotes, but its precise function is unclear. A human cDNA encoding a protein with 45% identity to the small subunit of yeast TFIIA has been isolated. TFIIA
J DeJong et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(8), 3313-3317 (1995-04-11)
The human general transcription factor TFIIA is one of several factors involved in specific transcription by RNA polymerase II, possibly by regulating the activity of the TATA-binding subunit (TBP) of TFIID. TFIIA purified from HeLa extracts consists of 35-, 19-
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