产品名称
β NGF 人, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized
potency
<1.0 ng/mL ED50
mol wt
(Noncovalent Homodimer, 13.6 kDa (121 amino acids))
packaging
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... NGF(4803)
Application
人β NGF 已被用于免疫组织化学。
Biochem/physiol Actions
β-NGF 是与 BDNF、NT-3 和 NT-4 结构相关的神经营养因子。人 b-NGF 的功能形式是非共价二硫键连接的同源二聚体，具有两个 13.5kDa 多肽单体（总共 240 个氨基酸残基）。这三个二硫键是生物活性所必需的。
General description
β-NGF 是与 BDNF、NT-3 和 NT-4 结构相关的神经营养因子。这些蛋白质属于生长因子的半胱氨酸结家族，其具有稳定的二聚体结构。β-NGF 是一种强神经营养因子，通过其受体 β-NGFR 传递信号，在感觉和交感神经系统的发育和保存中起着至关重要的作用。β-NGF 还作为 B 淋巴细胞的生长和分化因子，并促进 B 细胞的存活。人 β-NGF 的功能形式是非共价二硫键连接的同源二聚体，具有两个 13.5kDa 多肽单体（总共 240 个氨基酸残基）。这三个二硫键是生物活性所必需的。
Other Notes
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA
Physical form
冻干品，无添加剂。
Preparation Note
在打开之前离心小瓶。在水中重悬至浓度为 0.1-1.0 mg/ml。不要涡旋。该溶液可在 2-8℃ 下储存长达 1 周。要于长期储存，建议在含有载体蛋白（例如 0.1％ BSA）的缓冲液中进一步稀释，并以 工作等分试样储存于 -20°C 至 -80°C。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The nerve growth factor 35 years later.
R Levi-Montalcini
Science (New York, N.Y.), 237(4819), 1154-1162 (1987-09-04)
H Zhang et al.
European journal of histochemistry : EJH, 59(3), 2522-2522 (2015-10-03)
The nerve growth factor (NGF) not only has an essential effect on the nervous system, but also plays an important role in a variety of non-neuronal systems, such as the reproductive system. The aim of this study was to investigate
Huiyu Chen et al.
Journal of inflammation (London, England), 16, 27-27 (2020-01-01)
In herpes simplex epithelial keratitis, excessive TLR3-induced cellular responses after virus infection evoke inflammatory cascades that might be destructive to the host cornea. Nerve growth factor (NGF), a pluripotent neurotrophic factor with immune regulatory effect, was proved to be effective
A Ullrich et al.
Nature, 303(5920), 821-825 (1983-06-30)
Nerve growth factor (NGF) is thought to have a profound effect on the development and maintenance of sympathetic and embryonic sensory neurones (see refs 1-3 for review). NGF activity isolated from the male mouse submaxillary gland (MSG) consists of three
Monique Rascher et al.
Biomolecules, 10(10) (2020-10-18)
Medicinal mushrooms of the genus Hericium are known to produce secondary metabolites with homeostatic properties for the central nervous system. We and others have recently demonstrated that among these metabolites cyathane diterpenoids and in particular erinacine C possess potent neurotrophin
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