SRP3100
KGF 人
Animal-component free, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture
别名:
HBGF-7, 成纤维细胞生长因子 7, 角质形成细胞生长因子
生物来源
human
重组
expressed in E. coli
方案
≥95% (HPLC)
≥95% (SDS-PAGE)
表单
lyophilized
效能
≤10 ng/mL ED50
分子量
18.9 kDa
包装
pkg of 10 μg
技术
cell culture | mammalian: suitable
杂质
<0.1 EU/μg endotoxin, tested
颜色
off-white to yellow
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... FGF7(2252)
一般描述
成纤维细胞生长因子 7（FGF-7）是成纤维细胞生长因子家族的成员。FGF 家族成员具有广泛的促有丝分裂和细胞存活活性。编码该蛋白的基因位于人类染色体 15q21.1 上。
生化/生理作用
成纤维细胞生长因子（FGF）家族成员参与胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭等多种生物学过程。FGF7 是一种有效的上皮细胞特异性生长因子，其促有丝分裂活性主要表现在角质形成细胞中，而在成纤维细胞和内皮细胞中则没有。该蛋白质与成纤维细胞生长因子受体（FGFRs）结合并激活它们。对该基因的小鼠和大鼠同源物的研究表明，该基因在上皮的形态发生、伤口的表皮再生、头发的发育和早期肺器官发生等过程中起作用。
外形
从 15mM 磷酸钠，pH 7.0 + 0.25 M NaCl 中冻干。
制备说明
在打开之前将小瓶进行离心。用 1x PBS 进行重悬至浓度为 0.5-1.0 mg/ml。不要涡旋。该溶液可在2-8℃下储存最长达1周。如需更长时间的储存，建议使用含有稳定剂（如5％海藻糖）的缓冲液进行进一步的稀释，并在分装成工作体积后冻存在-20°C至-80°C。
其他说明
MCNDMTPEQM ATNVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
The Fibroblast Growth Factor signaling pathway.
Ornitz DM and Itoh N
Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 4(3), 215-266 (2015)
A family-based association study after genome-wide linkage analysis identified two genetic loci for renal function in a Mongolian population.
Park H
Kidney International, 83(2), 285-292 (2013)
Laxmi Yeruva et al.
mBio, 5(3), e01241-e01214 (2014-06-26)
It is not currently possible to predict the probability of whether a woman with a chlamydial genital infection will develop pelvic inflammatory disease (PID). To determine if specific biomarkers may be associated with distinct chlamydial pathotypes, we utilized two Chlamydia
Xiao-Jing Zhu et al.
PLoS genetics, 10(10), e1004687-e1004687 (2014-10-21)
Epidermal stratification of the mammalian skin requires proliferative basal progenitors to generate intermediate cells that separate from the basal layer and are replaced by post-mitotic cells. Although Wnt signaling has been implicated in this developmental process, the mechanism underlying Wnt-mediated
Shuichi Tobinaga et al.
Acta histochemica et cytochemica, 48(3), 83-94 (2015-07-15)
Pulmonary emphysema is a progressive disease with airspace destruction and an effective therapy is needed. Keratinocyte growth factor (KGF) promotes pulmonary epithelial proliferation and has the potential to induce lung regeneration. The aim of this study was to determine the
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