产品名称
PF-4 (CXCL4) 人, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
1.0-10.0 ng/mL
mol wt
7.8 kDa
packaging
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... PF4(5196)
Biochem/physiol Actions
血小板因子4（PF-4）对嗜中性粒细胞和单核细胞具有趋化作用，并已显示出抑制血管生成的作用。这种蛋白与肝素结合并中和。它还可以中和各种带负电荷的蛋白聚糖。
General description
血小板因子4（PF-4）是一种CXC趋化因子，在巨核细胞中表达并存储在血小板的α颗粒中。 编码该蛋白的基因位于人类4号染色体上4。重组人PF-4是一种7.8kDa蛋白，包含70个氨基酸残基，包括CXC趋化因子中存在的四个高度保守的残基。
Other Notes
EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES
Physical form
不含添加剂的冻干品。
Preparation Note
先离心，再开瓶。在水中重悬至浓度为0.1-1.0 mg/ml。请勿涡旋。该溶液可在2-8℃下储存长达1周。 对于长期储存，建议在含有载体蛋白（如0.1%BSA）的缓冲液中进一步稀释，分装为工作体积并在-20°C至-80°C下储存。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Chemokines and Chemokine Receptors
Manel Juan
Wiley Guide to Chemical Incompatibilities (2013)
S S Huang et al.
The Journal of biological chemistry, 257(19), 11546-11550 (1982-10-10)
A large scale purification procedure for the human platelet factor 4 proteoglycan carrier molecule has been developed. A yield of 46% and a 33,000-fold purification have been achieved, using poly-L-lysine-Sepharose affinity column chromatography, PF4-agarose affinity column chromatography, and Bio-Gel A-0.5m
Yong Du et al.
The Journal of experimental medicine, 219(7) (2022-06-01)
Chemokines control the migratory patterns and positioning of immune cells to organize immune responses to pathogens. However, many chemokines have been associated with systemic autoimmune diseases that have chronic IFN signatures. We report that a series of chemokines, including CXCL4
CXCL4 Plasma Levels Are Not Associated with the Extent of Coronary Artery Disease or with Coronary Plaque Morphology.
Erbel C
PLoS ONE, 10(11), e0141693-e0141693 (2015)
B Scheuerer et al.
Blood, 95(4), 1158-1166 (2000-02-09)
Unstimulated monocytes rapidly undergo physiological changes resulting in programmed cell death (apoptosis) while stimuli promoting differentiation of these cells into macrophages were shown to inhibit apoptotic processes. In the present study, we report that the platelet-derived alpha-chemokine platelet factor 4
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