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一般描述
血小板因子4(PF-4)是一种CXC趋化因子,在巨核细胞中表达并存储在血小板的α颗粒中。 编码该蛋白的基因位于人类4号染色体上4。重组人PF-4是一种7.8kDa蛋白,包含70个氨基酸残基,包括CXC趋化因子中存在的四个高度保守的残基。
生化/生理作用
血小板因子4(PF-4)对嗜中性粒细胞和单核细胞具有趋化作用,并已显示出抑制血管生成的作用。这种蛋白与肝素结合并中和。它还可以中和各种带负电荷的蛋白聚糖。
序列
EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES
外形
不含添加剂的冻干品。
重悬
先离心,再开瓶。在水中重悬至浓度为0.1-1.0 mg/ml。请勿涡旋。该溶液可在2-8℃下储存长达1周。 对于长期储存,建议在含有载体蛋白(如0.1%BSA)的缓冲液中进一步稀释,分装为工作体积并在-20°C至-80°C下储存。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Chemokines and Chemokine Receptors
Wiley Guide to Chemical Incompatibilities (2013)
Blood, 95(4), 1158-1166 (2000-02-09)
Unstimulated monocytes rapidly undergo physiological changes resulting in programmed cell death (apoptosis) while stimuli promoting differentiation of these cells into macrophages were shown to inhibit apoptotic processes. In the present study, we report that the platelet-derived alpha-chemokine platelet factor 4
The Journal of biological chemistry, 257(19), 11546-11550 (1982-10-10)
A large scale purification procedure for the human platelet factor 4 proteoglycan carrier molecule has been developed. A yield of 46% and a 33,000-fold purification have been achieved, using poly-L-lysine-Sepharose affinity column chromatography, PF4-agarose affinity column chromatography, and Bio-Gel A-0.5m
CXCL4 Plasma Levels Are Not Associated with the Extent of Coronary Artery Disease or with Coronary Plaque Morphology.
PLoS ONE, 10(11), e0141693-e0141693 (2015)
CXCL4-platelet factor 4, heparin-induced thrombocytopenia and cancer.
Thrombosis Research, 129, S97-100 (2012)
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