SRP3211
IL-4 来源于小鼠
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
别名:
B 细胞刺激因子, BCDF, BCGF
产品名称
IL-4 来源于小鼠, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
≤2.0 ng/mL ED50
mol wt
13.7 kDa
packaging
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... IL4(16189)
Biochem/physiol Actions
它调节多种 T 和 B 细胞应答，包括细胞增殖、存活和基因表达。IL-4 调节初始 CD4 + T 细胞分化为辅助性 Th2（T 辅助）细胞，其特征为细胞因子分泌配置文件，包括 IL-4、IL-5、IL-6、IL-10 和 IL-13 的分泌，有利于体液免疫应答。IL-4 的另一个主要功能是调节免疫球蛋白类别转换为 IgG1（免疫球蛋白 G1）和 IgE 同种型。Th2 细胞产生过多的 IL-4 与 IgE 产生升高和过敏有关。IL-4 通过控制小胶质细胞/巨噬细胞的活性有助于脑缺血后的长期恢复。在小鼠中，IL-4 的缺失与一种状态类焦虑行为相关。
General description
IL-4（白介素4）是一种多效价细胞因子，由肥大细胞、T细胞和骨髓基质细胞产生。重组鼠IL-4是含有120个氨基酸残基的13.7kDa球状蛋白质。
Other Notes
MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK knsssvlmelq RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S
Physical form
不含添加剂的冻干品。
Preparation Note
打开前离心小瓶。用水复溶至 0.1-1.0 mg/mL 浓度。切勿涡旋。该溶液可在 2-8°C 条件下至多储存 1 周。对于长期储存，建议在含有稳定剂（例如 5% 海藻糖）的缓冲液中进一步稀释，并在-20°C 至-80°C 下储存。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
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Using gas chromatography mass spectrometry (GC-MS) to analyze the citric acid cycle (CAC) and related intermediates (such as glutamate, glutamine, GABA, and aspartate) is an analytical approach to identify unexpected correlations between apparently related and unrelated pathways of energy metabolism.
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Chromosome conformation capture combined with high-throughput sequencing (4C-seq) is a powerful tool to map genomic DNA regions that communicate with a specific locus of interest such as functional single-nucleotide polymorphism (SNPs)-containing regions. This protocol describes detailed steps to perform 4C-seq
Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma.
Mitsuyasu H
Nature Genetics, 19, 119-120 (1998)
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