SRP4251
MIP-2 from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
别名:
CXCL2, Gro-β, Growth- regulated protein β, MIP2-α, Macrophage inflammatory protein 2-α, chemokine (C-X-C motif) ligand 2
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关于此项目
Form:
lyophilized
Assay:
≥98% (HPLC), ≥98% (SDS-PAGE)
Biological source:
mouse
Recombinant:
expressed in E. coli
Mol wt:
~7.8 kDa
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (HPLC), ≥98% (SDS-PAGE)
form
lyophilized
mol wt
~7.8 kDa
packaging
pkg of 20 μg
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Cxcl2(20310)
General description
MIP-2 (microphage inflammatory protein-2), or Cxcl2 ((C-X-C motif) ligand 2), was initially recognized as a 6kDa protein released by an LPS (lipopolysaccharide)-stimulated mouse macrophage cell line. It belongs to the chemokine family which contains 6-14kDa, heparin-binding cytokines. It is a member of the a (CXC) chemokine family, where any amino acid separates both conserved cysteines.
Mouse MIP-2 is a 7.8kDa protein containing 73 amino acid residues including the ‘RLR′ motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.
Mouse MIP-2 is a 7.8kDa protein containing 73 amino acid residues including the ‘RLR′ motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.
Biochem/physiol Actions
MIP-2 (microphage inflammatory protein-2), or Cxcl2 ((C-X-C motif) ligand 2), is a functional homolog of human IL-8 (interleukin) in mice, and like human IL-8 it induces a potent neutrophil chemotactic activity. It might be critical in the recruitment and influx of immune cells in inflammation and infection. Murine encephalomyelitis virus of Theiler (TMEV) induces the expression of MIP-2 in genetically susceptible but not in resistant mouse strains. In mice, in acute and chronic liver injury, TLR2 (Toll-like receptor)/S100A9/MIP-2 signaling pathways is crucial for neutrophil recruitment, and this might have therapeutic implications in selectively manipulating neutrophils in liver disease while circumventing normal wound healing and regenerative responses.
Physical form
Sterile filtered and then lyophilized without additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1 mg/mL. The solution can be diluted into other aqueous buffers.