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安全信息

SRP4365

Sigma-Aldrich

VEGF165 from rat

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

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别名:
MGC70609, VEGF, VEGF-A, VPF, Vascular endothelial growth factor A, Vascular permeability factor
NACRES:
NA.32

生物来源

rat

重组

expressed in E. coli

检测方案

≥98% (SDS-PAGE)

形式

lyophilized

分子量

~38.4 kDa

包装

pkg of 10 μg

储存条件

avoid repeated freeze/thaw cycles

杂质

endotoxin, tested

NCBI登记号

P16612

运输

wet ice

储存温度

−20°C

基因信息

rat ... Vegfa(83785)

相关类别

一般描述

VEGF165 (vascular endothelial growth factor 165), also known as VEGF-A, is a homodimeric glycoprotein and is expressed as multiple splice variants. Recombinant rat VEGF is a double, non-glycosylated, polypeptide containing 164 amino acids and having a molecular mass of 38.4kDa.

应用

VEGF165 (vascular endothelial growth factor 165) has been used to study the effects of VEGF on the morphology and survival of neurons and glial cells.

生化/生理作用

VEGF165 (vascular endothelial growth factor 165) has been shown to have pro-angiogenic properties. It has a role in the proliferation of endothelial cells and neuroprotection.

外形

Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

重悬

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Different angiogenic pathways characterize superficial and invasive bladder cancer.
O'Brien T
Cancer Research, 55(3), 510-513 (1999)
Sarah A Figley et al.
PloS one, 9(5), e96137-e96137 (2014-05-23)
Following spinal cord injury (SCI) there are drastic changes that occur in the spinal microvasculature, including ischemia, hemorrhage, endothelial cell death and blood-spinal cord barrier disruption. Vascular endothelial growth factor-A (VEGF-A) is a pleiotropic factor recognized for its pro-angiogenic properties;
Hongxiu Han et al.
The American journal of pathology, 191(3), 515-526 (2020-12-22)
Nerve infiltration into the tumor is a common feature of the tumor microenvironment. The mechanisms of axonogenesis in breast cancer remain unclear. We hypothesized that vascular endothelial growth factor (VEGF), as well as nerve growth factor (NGF), is involved in
Larisa Antonova et al.
Pharmaceuticals (Basel, Switzerland), 14(4) (2021-04-04)
Tissue-engineered vascular grafts are widely tested as a promising substitute for both arterial bypass and replacement surgery. We previously demonstrated that incorporation of VEGF into electrospun tubular scaffolds from poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(ε-caprolactone) enhances formation of an endothelial cell monolayer. However, an overdose
Pauline Latzer et al.
CNS neuroscience & therapeutics, 22(6), 440-450 (2016-02-11)
Vascular endothelial growth factor (VEGF) is a hallmark of glioblastoma multiforme (GBM) and plays an important role in brain development and function. Recently, it has been reported that treatment of GBM patients with bevacizumab, an anti-VEGF antibody, may cause a
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