生物来源
mouse
重组
expressed in E. coli
方案
≥95% (HPLC)
≥95% (SDS-PAGE)
表单
lyophilized
分子量
~22.5 kDa
包装
pkg of 50 μg
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
NCBI登记号
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Prl(256249)
一般描述
Prolactin (PRL, also known as mammotrophin, luterotropic hormone, and lutetropin) is a neuroendocrine hormone secreted by the pituitary gland. It belongs to the cytokine receptor superfamily. Recombinant mouse prolactin is a 22.5kDa globular protein containing 198 amino acid residues.
应用
PRL (Prolactin) from mouse has been used to study the effects of prolactin on the length, motility and viability of larvae of Toxocara canis.
Prolactin from mouse has been used as a supplement in mammary epithelial basal medium (MEBM) for mammary epithelial cell culture.
生化/生理作用
PRL (Prolactin) primary function is to promote and maintain lactation during pregnancy and suckling. In addition, prolactin plays an immune-regulatory role by stimulating the activities of ornithine decarboxylase and protein kinase C, which are important for the proliferation, differentiation, and function of lymphocytes. In mice, prolactin also prevents hepatocellular carcinoma by suppressing MAP3K (mitogen-activated protein kinase kinase kinase)-dependent activation of c-myc.
Prolactin synthesis is regulated in the hypothalamus. Dopamine and prolactin secretion from anterior pituitary lactotrophs are controlled by a negative feedback loop. Prolactin modulates xenobiotic metabolism by controlling the mRNA expression cytochrome p450 enzymes.
外形
Sterile filtered and lyophilized from 10 mM Sodium Phosphate, pH 8.0 plus 50 mM NaCl.
制备说明
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
涉药品监管产品
此项目有
Prolactin levels correlate with abnormal B cell maturation in MRL and MRL/lpr mouse models of systemic lupus erythematosus-like disease.
Legorreta-Haquet MV
Clinical & Developmental Immunology, doi: 10- doi: 10 (2013)
L E Chávez-Güitrón et al.
Experimental parasitology, 198, 1-6 (2019-01-12)
The in vitro effect of progesterone in T. canis larvae on their enlargement and motility were evaluated, together to the possible presence of progesterone receptors (PRs). T. canis larvae were cultured in RPMI-1640 with different concentrations of progesterone (0, 20
Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C.
Rillema JA
Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine, 178, 490-490 (1095)
Chromosome segregation fidelity in epithelia requires tissue architecture
Knouse KA, et al.
Cell, 175(1), 200-211 (2018)
Hui Li et al.
American journal of physiology. Gastrointestinal and liver physiology, 320(2), G183-G192 (2020-11-19)
Gastric vagal afferents (GVAs) sense food-related mechanical stimuli and signal to the central nervous system, to integrate control of meal termination. Pregnancy is characterized by increased maternal food intake, which is essential for normal fetal growth and to maximize progeny
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持