SRP4688
催乳素 来源于小鼠
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
别名:
Luterotropic hormone, Lutetropin, Mammotropin, PRL
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥95% (HPLC), ≥95% (SDS-PAGE)
Biological source:
mouse
Recombinant:
expressed in E. coli
Mol wt:
~22.5 kDa
biological source
mouse
recombinant
expressed in E. coli
assay
≥95% (HPLC), ≥95% (SDS-PAGE)
form
lyophilized
mol wt
~22.5 kDa
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Prl(256249)
General description
Prolactin (PRL, also known as mammotrophin, luterotropic hormone, and lutetropin) is a neuroendocrine hormone secreted by the pituitary gland. It belongs to the cytokine receptor superfamily. Recombinant mouse prolactin is a 22.5kDa globular protein containing 198 amino acid residues.
Application
PRL (Prolactin) from mouse has been used to study the effects of prolactin on the length, motility and viability of larvae of Toxocara canis.
Prolactin from mouse has been used as a supplement in mammary epithelial basal medium (MEBM) for mammary epithelial cell culture.
Biochem/physiol Actions
PRL (Prolactin) primary function is to promote and maintain lactation during pregnancy and suckling. In addition, prolactin plays an immune-regulatory role by stimulating the activities of ornithine decarboxylase and protein kinase C, which are important for the proliferation, differentiation, and function of lymphocytes. In mice, prolactin also prevents hepatocellular carcinoma by suppressing MAP3K (mitogen-activated protein kinase kinase kinase)-dependent activation of c-myc.
Prolactin synthesis is regulated in the hypothalamus. Dopamine and prolactin secretion from anterior pituitary lactotrophs are controlled by a negative feedback loop. Prolactin modulates xenobiotic metabolism by controlling the mRNA expression cytochrome p450 enzymes.
Physical form
Sterile filtered and lyophilized from 10 mM Sodium Phosphate, pH 8.0 plus 50 mM NaCl.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Prolactin transport into mouse brain is independent of prolactin receptor.
Brown RS
Faseb Journal, 30, 1002-1010 (2016)
Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice.
Hartwell HJ
Proceedings of the National Academy of Sciences of the USA, 111, 11455-11455 (2014)
Prolactin upregulates female-predominant P450 gene expressions and downregulates male-predominant gene expressions in mouse liver
Sato Y, et al.
Drug Metabolism and Disposition, 45(6), 586-592 (2017)
Chromosome segregation fidelity in epithelia requires tissue architecture
Knouse KA, et al.
Cell, 175(1), 200-211 (2018)
Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C.
Rillema JA
Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine, 178, 490-490 (1095)
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