Merck
CN
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文件

安全信息

SRP5010

Sigma-Aldrich

CDK2/CyclinA1, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

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别名:
p33(CDK2)
NACRES:
NA.32

重组

expressed in baculovirus infected Sf9 cells

产品线

PRECISIO® Kinase

检测方案

≥70% (SDS-PAGE)

形式

buffered aqueous glycerol solution

specific activity

70-95 nmol/min·mg

分子量

~58 kDa (CDK1)
 ~81 kDa (CyclinA1)

NCBI登记号

BC036346
NM_001798

运输

dry ice

储存温度

−70°C

Gene Information

human ... CCNA1(8900) , CDK2(1017)

一般描述

CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). CDK2 phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition.

外形

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

制备说明

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

法律信息

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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B Levkau et al.
Molecular cell, 1(4), 553-563 (1998-07-14)
Apoptosis of human endothelial cells after growth factor deprivation is associated with rapid and dramatic up-regulation of cyclin A-associated cyclin-dependent kinase 2(cdk2) activity. In apoptotic cells, the C termini of the cdk inhibitors p21Cip1/Waf1 and p27Kip1 are truncated by specific
Haojie Huang et al.
Science (New York, N.Y.), 314(5797), 294-297 (2006-10-14)
The function of cyclin-dependent kinase 2 (CDK2) is often abolished after DNA damage. The inhibition of CDK2 plays a central role in DNA damage-induced cell cycle arrest and DNA repair. However, whether CDK2 also influences the survival of cells under

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