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Merck
CN

SRP5074

PTPN13 (2169-2485), active, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

DKFZp686J1497, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE

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关于此项目

NACRES:
NA.77
UNSPSC Code:
12352200

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产品名称

PTPN13 (2169-2485), active, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

recombinant

expressed in E. coli

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

2040-2760 nmol/min·mg

mol wt

~61 kDa

NCBI accession no.

NM_080683

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PTPN13(5783)

General description

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN13 is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. PTPN13 binds to a negative regulatory domain in Fas that inhibits Fas-induced apoptosis.

Physical form

Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

存储类别

10 - Combustible liquids

wgk

WGK 1

法规信息

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分析证书(COA)

Lot/Batch Number
B287-1

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J Saras et al.
The Journal of biological chemistry, 269(39), 24082-24089 (1994-09-30)
A novel cytoplasmic protein tyrosine phosphatase (PTP), PTPL1, was identified and cloned using a polymerase chain reaction-based approach. Overlapping cDNA clones encompass an open reading frame of 7398 base pairs, predicting a protein of 2466 amino acid residues with a
J Inazawa et al.
Genomics, 31(2), 240-242 (1996-01-15)
PTPN13 is a protein tyrosine phosphatase that associates with the C-terminal negative regulatory domain in the Fas (APO-1/CD95) receptor. The PTPN13 protein contains six GLGF repeats that have been found in the rat postsynaptic density protein (PSD-95) and the Drosophila

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