生物来源
human
重组
expressed in E. coli
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
分子量
~24 kDa
NCBI登记号
应用
cell analysis
运输
dry ice
储存温度
−70°C
基因信息
human ... RAC3(5881)
一般描述
RAC3 is a GTPase which belongs to the RHO family of small GTP-binding proteins that regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. RAC3 is primarily expressed in brain and is proposed to play a specific function in neuronal cells. Depletion of RAC3 induces stronger cell adhesion and dramatically increases the outgrowth of neurite-like protrusions whereas overexpression of RAC3 results in a contractile round morphology. RAC3 can exert its function through negatively affecting integrin-mediated cell-matrix adhesions. RAC3 shares with RAC1 the ability to interfere with cadherin-mediated adhesion.
外形
Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling.
Amra Hajdo-Milasinovic et al.
Journal of cell science, 122(Pt 12), 2127-2136 (2009-06-06)
Rac1 and Rac3 are highly homologous regulatory proteins that belong to the small GTPases of the Rho family. Previously, we showed that Rac3 induces cell rounding and prevents neuronal differentiation, in contrast to its close relative Rac1, which stimulates cell
Encarnación Lozano et al.
Journal of cell science, 121(Pt 7), 933-938 (2008-03-06)
E-cadherin cell-cell adhesion plays a major role in the maintenance of the morphology and function of epithelial tissues. Modulation of E-cadherin function is an important process in morphogenesis and tumour de-differentiation. We have previously shown that constitutively active Rac1 induces
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